Od potencijala do vrhunske izvedbeFrom Potential to Peak Performance
FLIP je međunarodno, multidisciplinarno istraživanje starenja skeletnih mišića te učinaka specifičnih terapijskih protokola na biomarkere starenja.FLIP is an international, multidisciplinary study of skeletal-muscle aging and the effects of specific therapeutic protocols on aging biomarkers.
Sažetak projektaProject summary
Starenje je složen biološki proces pod utjecajem genetskih, okolišnih i životnih čimbenika, pri čemu mišićno tkivo s vremenom pokazuje progresivno funkcionalno propadanje. Projekt FLIP usmjeren je na razvoj inovativnih metoda za procjenu mišićne dobi i evaluaciju učinaka ciljnih intervencija — uranjanja u hladnu vodu, infracrvene saune, terapije crvenim svjetlom i hiperbarične oksigenoterapije (HBOT) — na biomarkere starenja.
Aging is a complex biological process shaped by genetic, environmental and lifestyle factors, in which muscle tissue undergoes progressive functional decline over time. The FLIP project focuses on developing innovative methods for assessing muscle age and evaluating the effects of targeted interventions — cold-water immersion, infrared sauna, red-light therapy and hyperbaric oxygen therapy (HBOT) — on aging biomarkers.
Ključni ciljevi uključuju:Key objectives include:
- Uspostavu Hrvatskog laboratorija za dugovječnost i zdravlje.Establishing the Croatian Laboratory for Longevity and Health.
- Analizu povezanosti biomarkera starenja i funkcionalnih pokazatelja skeletne muskulature.Analysing the relationship between aging biomarkers and functional indicators of skeletal musculature.
- Usporedbu između različitih skupina ispitanika, uključujući i parove blizanaca, kako bi se istražili genetski i okolišni čimbenici starenja.Comparing different groups of participants, including pairs of twins, to investigate the genetic and environmental factors of aging.
- Procjenu učinaka specifičnih protokola na karakteristike mišićnog tkiva i biomarkere starenja.Assessing the effects of specific protocols on muscle-tissue characteristics and aging biomarkers.
- Unaprjeđenje metodologije procjene mišićne dobi primjenom suvremenih instrumenata, statističkih metoda i specifičnih protokola.Advancing the muscle-age assessment methodology through modern instruments, statistical methods and specific protocols.
Ova longitudinalna, eksperimentalna i interdisciplinarna studija kombinira analizu bioloških uzoraka, testiranje neuromišićne funkcije i kontinuirano fiziološko praćenje kako bi se istražila dinamika starenja mišića. Koristit će se napredni dijagnostički alati, uključujući TMG, EMG, MyotonPRO, KINVENT, BauSport Sonicbone, termografiju i Bodyscanner, uz procjenu biološke dobi iz uzoraka krvi i sline. Psihološke i sociološke analize dodatno će istražiti ulogu mentalnih i društvenih čimbenika u procesu starenja.
This longitudinal, experimental and interdisciplinary study combines the analysis of biological samples, neuromuscular function testing and continuous physiological monitoring to explore the dynamics of muscle aging. Advanced diagnostic tools will be used, including TMG, EMG, MyotonPRO, KINVENT, BauSport Sonicbone, thermography and a Bodyscanner, together with biological-age assessment from blood and saliva samples. Psychological and sociological analyses will further explore the role of mental and social factors in the aging process.
FLIP teži uspostavi standardiziranog okvira za procjenu mišićne dobi, povećanju dijagnostičke preciznosti i istraživanju utjecaja ciljanih intervencija namijenjenih usporavanju procesa starenja. Rezultati će imati značajne implikacije za sportsku znanost, rehabilitaciju i preventivnu medicinu, povezujući sportsku fiziologiju, biomedicinu i tehnologiju. Promicanjem dugovječnosti, FLIP nastoji optimizirati sportsku izvedbu te produžiti trajanje i kvalitetu sportskih karijera i općeg zdravlja.
FLIP aims to establish a standardised framework for muscle-age assessment, increase diagnostic precision and investigate the effects of targeted interventions intended to slow the aging process. The results will have significant implications for sports science, rehabilitation and preventive medicine, connecting sports physiology, biomedicine and technology. By promoting longevity, FLIP seeks to optimise athletic performance and extend the duration and quality of sporting careers and general health.
Biološka dob i longevitetBiological age & longevity
Razumijevanje mehanizama dugovječnosti i pouzdano mjerenje „prave” biološke dobi danas su prepoznati kao ključni izazovi u istraživanju starenja. Sve veća pozornost pridaje se holističkom pristupu koji povezuje funkcionalne testove, molekularne biomarkere i podatke o životnom stilu.
Understanding the mechanisms of longevity and reliably measuring „true” biological age are recognised as key challenges in aging research. A holistic approach is increasingly favoured — integrating functional tests, molecular biomarkers and lifestyle data.
Starenje mišićnog sustava složen je proces u kojem se isprepliću genetski, epigenetski i okolišni čimbenici, a ključna posljedica je postupni pad snage, elastičnosti i funkcionalne sposobnosti skeletnih mišića.
Aging of the muscular system is a complex process interweaving genetic, epigenetic and environmental factors, with a key consequence being the progressive decline in strength, elasticity and functional capacity of skeletal muscles.
Prethodni HRZZ projektiPrevious HRZZ projects
FLIP je logičan nastavak HRZZ projekata IP-2020-02-3366 („Biološka, kronološka i relativna dob u uspostavi hrvatskog sustava sportskih talenata”) i IP-2024-05-8340 („The Interplay of Genetics, Biological Age, and Muscle Fiber Characteristics in Talent Development and Athletic Performance”), u sklopu kojih je uspostavljen Cro Sport Talent & Longevity Health Lab.
FLIP is a logical continuation of the HRZZ projects IP-2020-02-3366 („Biological, chronological and relative age in establishing the Croatian sports talent system”) and IP-2024-05-8340 („The Interplay of Genetics, Biological Age, and Muscle Fiber Characteristics in Talent Development and Athletic Performance”), through which the Cro Sport Talent & Longevity Health Lab was established.
Pet ciljeva projektaFive project objectives
Biomarkeri i funkcijaBiomarkers & function
Analizirati odnos između biomarkera starenja i funkcionalnih pokazatelja skeletne muskulature.
Analyse the relationship between aging biomarkers and functional indicators of skeletal musculature.
Usporedba dobnih skupinaCompare age groups
Usporediti podatke različitih dobnih skupina kako bi se istražili čimbenici koji utječu na starenje.
Compare data across age groups to investigate factors influencing aging.
Učinci protokolaProtocol effects
Ocijeniti učinke hladne vode, crvenog svjetla, infracrvene saune i HBOT-a na svojstva mišićnog tkiva i biomarkere.
Evaluate effects of cold water, red light, infrared sauna and HBOT on muscle-tissue properties and biomarkers.
Unaprjeđenje metodologijeAdvance the methodology
Unaprijediti metodologiju procjene starosti mišića suvremenim dijagnostičkim instrumentima, statističkim metodama i strojnim učenjem — kroz razvoj kompozitnog indeksa starosti mišića.
Advance the muscle-age assessment methodology using modern diagnostics, statistics and machine learning — through a composite muscle age index.
Zašto je FLIP posebanWhat makes FLIP distinctive
Spoj suvremenih tehnologija, terapijskih protokola i naprednih statističkih metoda — uz integraciju kineziologije, biomedicine, biotehnologije i neuroznanosti.
A combination of modern technologies, therapeutic protocols and advanced statistics — integrating kinesiology, biomedicine, biotechnology and neuroscience.
MultidisciplinarnoMultidisciplinary
Četiri znanstvena polja, tri države, jedinstven mjerni instrument.
Four scientific fields, three countries, one unified instrument.
KomercijalnoCommercial
Suradnja s proizvođačima opreme (TMG, SonicBone) i razmjena podataka.
Collaboration with device makers (TMG, SonicBone) and data sharing.
DruštvenoSocietal
Primjena u javnom zdravstvu, sportu i kvaliteti života starijih.
Applications in public health, sport and quality of life for older adults.
ObrazovnoEducational
Mladi istraživači — doktorandi i poslijedoktorandi — uče uz iskusne kolege.
Early-career researchers — PhD & postdoc — learn alongside senior peers.
Tri godine, tri fazeThree years, three phases
Uspostava i pripremaSetup & preparation
Nabava i instalacija opreme (TMG, MyotonPRO, termografska kamera, nosivi senzori), uspostava laboratorija, izrada mjernih protokola, pilot-studije, obuka mjeritelja i etička odobrenja.
Procurement and installation of equipment (TMG, MyotonPRO, thermal camera, wearables), lab setup, measurement protocols, pilot studies, operator training and ethical approvals.
Intervencije i mjerenjaInterventions & measurements
Probir sudionika, 60-dnevne intervencije (hladna voda, infracrvena sauna, crveno svjetlo, HBOT), inicijalna i ponovljena mjerenja u Splitu i Zagrebu.
Participant screening, 60-day interventions (cold water, infrared sauna, red light, HBOT), initial and repeated measurements in Split and Zagreb.
Modeli i diseminacijaModels & dissemination
Napredna analiza podataka, integracija fenotipskih i molekularnih podataka, kompozitni indeks starosti mišića, strojno učenje, objava radova i diseminacija rezultata.
Advanced data analysis, integration of phenotypic and molecular data, composite muscle age index, machine learning, publications and dissemination.